Publications from VPCC investigators
A selection of relevant research materials from VPCC investigators.
Dr Jason Cain
Sun, C X, Daniel P, Bradshaw G, Gough D, Cain J E … Firestein R (2023). Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities. Cancer Cell 2023 Mar 22;S1535-6108(23)00080-6
Cochrane C.R., Vaghjiani V, Szczepny A, Jayasekara W.S.N, Gonzalez-Rajal A, Kikuchi K, McCaughan G.W., Burgess A, Gough D.J., Watkins D.N., Cain J.E. et al. (2020). Trp53 and Rb1 Regulate Autophagy and Ligand-Dependent Hedgehog Signaling. Journal of Clinical Investigation, 22:132513.
Marini K.D., Croucher D.R., McCloy R.A., Vaghjiani V, Gonzalez-Rajal A, Hastings J.F., Chin V, Szczepny A, Kostyrko K, Marquez C, Jayasekara W.S.N., Alamgeer M, Boolell V, Han J.Z.R., Waugh T, Lee H.C., Oakes S.R., Kumar B, Harrison C.A. … Cain, J.E. & Watkins D.N. (2018). Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy. Science Translational Medicine, 10(451).
Szczepny A, Carey K, McKenzie L, Jayasekara W.S.N, Rossello F, Gonzalez-Rajal A, McCaw A.S, Popovski D, Wang D, Sadler A.J., Mahar A, Russell P.A., Wright G, McCloy R.A., Garama D.J., Gough, D.J., Stephen B. Baylin, Burgess A, Cain, J.E. & Watkins D.N. (2018). The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53. Oncogene.
Ramaswamy, V, Hielscher, T, Mack S.C., Lassaletta A, Lin T, Pajtler K.W., Jones D.T.W, Luu B, Cavalli F.M.G., Aldape K, Remke M, Mynarek M, Rutkowski S, Gururangan S, McLendon R.E., Lipp E.S., Dunham C, Hukin J, Eisenstat D.D., … Cain, J.E. … Taylor M.D. (2016). Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era. Journal of Clinical Oncology, 34(21):2468-77.
Prof Bruce Carleton
Siemens A, Brooks B, Rassekh SR, Meijer AJM, van den Heuvel-Eibrink MM, Xu W, Loucks CM, Ross CJD, Carleton BC on behalf of the Canadian Pharmacogenomics Network for Drug Safety Consortium (2023). Role of cisplatin dose intensity and TPMT variation in the development of hearing loss in children. Ther Drug Monit. Mar 7. [Online ahead of print]. PMID: 36917731
Siemens A, Rassekh SR, Ross CR, Carleton BC (2023). Development of a Dose-adjusted Polygenic Risk-model for Anthracycline-induced Cardiotoxicity. Ther Drug Monit. Jan 12. [Online ahead of print]. PMID: 36728273
Barker CIS, Groeneweg G, Maitland-van der Zee AH, Rieder MJ, Hawcutt DB, Hubbard TJ, Swen JJ, Carleton BC (2022). Pharmacogenomic Testing in Paediatrics: Clinical Implementation Strategies. Br J Clin Pharmcol. Oct;88(10):4297-4310. PMID: 34907575
Meijer AJM, Li KH, Brooks B, Clemens E, Ross CJ, Rassekh SR, Hoetink AE, van Grotel M, can den Heuvel-Eibrink MM, Carleton BC (2022). The cumulative incidence of cisplatin-induced hearing loss in young children is higher and develops at an early stage during therapy compared with older children based on 2052 audiological assessments. Cancer Jan 1;128(1):169-179. PMID:34490624
Magdy T, Jiang Z, Jouni M, Fonoudi H, Lyra-Leite D, Jung G, Romero-Tejeda M, Kuo HH, Fetterman KA, Gharib M, Burmeister BT, Zhao M, Sapkota Y, Ross CJ, Carleton BC, Bernstein D, Burridge PW (2021). RARG variant predictive of doxorubicin-induced cardiotoxicity identifies a cardioprotective therapy. Cell Stem Cell. Dec 2;28(12):2076-2089. PMID: 34525346
Magdy T, Jouni M, Kuo HH, Weddle CJ, Lyra-Leite D, Fonoudi H, Romero-Tejeda M, Gharib M, Javed H, Fajardo G, Ross CJD, Carleton BC, Bernstein D, Burridge PW (2022). Identification of Drug Transporter Genomic Variants and Inhibitors that Protect Against Doxorubicin-Induced Cardiotoxicity. Circulation. Jan 25;145(4):279-294. PMID: 34874743
A/Prof Rachel Conyers
Foulkes, S, Costello B.T., Howden E.J., Janssens K, Dillon H, Toro C, Claus P, Fraser S.F., Daly R.M., Elliott D.A., Conyers R, La Gerche A. (2020). Exercise CMR reveals reduced cardiac reserve in paediatric cancer survivors with impaired cardiopulmonary fitness. Journal of Cardiac Magnetic Resonance Imaging, 22(1):64.
McOwan, T.N., Craig L.A., Tripdayonis A, Karavendzas K, Cheung M.M., Porrello E.R., Conyers R, Elliott D.A. (2020). Evaluating anthracycline associated single nucleotide polymorphisms in a paediatric cohort with early onset cardiomyopathy. Cardio-Oncology, 6(5).
Tenzin, G, Sepulveda F.E., Khuong-Quang D-A, Pratt J, Valera E.T., Garrigue A, Kelso S, Sicheri F, Mikael L.G., Hamel N, Bajic A, Dali R, Deshmukh S, Dervovic D, Schramek D, Guerin F, Taipale M, Nikbakht H, Majewski J … Conyers, R … Jabado N. (2019). Germline HAVCR2 mutations altering TIM-3 characterise subcutaneous panniculitis-like T cell Lymphoma with haemophagocytic lymphohistiocytosis. Nature Genetics, 50(12):1650-1657. Impact Factor 27.15, Citation 19. Breakthrough study identifying TIM-3 as genetic variant predisposing patients with PLTCL to HLH
Conyers, R., Devaraja S, Elliott, D. (2018). Systematic Review of Pharmacogenomics and Adverse Drug reactions in Paediatric Oncology Patients. Pediatric Blood & Cancer, 65(4):e26937
Tripaydonis, A, Conyers, R., Elliott, D.A. (2018). Pediatric Anthracycline induced Cardiotoxicity: Mechanisms, Pharmacogenomics and Pluripotent Stem-Cell Modelling. Clinical Pharmacology & Therapeutics, 105(3):614-624.
Prof Roger Daly
Ma X, Zhang L, Song J, Nguyen E, Lee R.S., Rodgers S.J., Li F., Huang C, Schittenhelm R.B., Chan H, Chheang C, Wu J, Brown K.K., Mitchell C.A., Simpson K.J., Daly RJ et al (2019). Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation. Nat Commun. Jan 17;10(1):296.
Patel O, Griffin M.D.W., Panjikar S, Dai W, Ma X, Chan H, Zheng C, Kropp A, Murphy J.M., Daly RJ, Lucet IS (2017). Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association. Nat Commun. Oct 27;8(1):1157.
Fleuren EDG, Vlenterie M, van der Graaf W.T.A, Hillebrandt-Roeffen M.H.S, Blackburn J, Ma X, Chan H, Magias M.C., van Erp A, van Houdt L, Cebeci S.A.S, van de Ven A, Flucke U.E, Heyer E.E, Thomas D.M, Lord C.J, Marini K.D, Vaghjiani V, Mercer T.R. … Daly RJ et al (2017). Phosphoproteomic Profiling Reveals ALK and MET as Novel Actionable Targets across Synovial Sarcoma Subtypes. Cancer Res. 217 Aug 15;77(16):4279-4292.
Zheng Y, Zhang C, Croucher D.R, Soliman M.A, St-Denis N, Pasculescu A, Taylor L, Tate S.A., Hardy W.R., Colwill K, Dai A.Y., Bagshaw R, Dennis J.W., Gingras A-C, Daly RJ, Pawson T et al (2013). Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature. Jul 11;499(7457):166-71.
Hochgräfe F, Zhang L, O’Toole S.A, Browne B.C., Pinese M, Cubas A.P., Lehrbach G.M., Croucher D.R., Rickwood D, Boulghourjian A, Shearer R, Nair R, Swarbrick A, Faratian D, Mullen P, Harrison D.J., Biankin A.V., Sutherland R.L., Raftery M.J. Daly RJ et al (2010). Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells. Cancer Res. Nov 15;70(22):9391-401.
Prof Tracey Danaher
Stuart B, Danaher T.S., Awdish R, Berry L. (2019). Finding Hope and Healing When Cure is Not Possible. Mayo Clinic Proceedings, 94(4): 677-685.
Berry L.L, Deming K.A., Danaher T.S., et al. (2018). Improving Nonclinical and Clinical-Support Services: Lessons from Oncology. Mayo Clinic Proceedings: Innovations, Quality and Outcomes, 2(3):207-217.
Berry L.L, Danaher T.S., Beckham D, Awdish R.L.A, Mate, K. S. (2017). When Patients and Their Families Feel like Hostages to Health Care. Mayo Clinic Proceedings, 9(9):1373–1381.
Berry L.L, Danaher T.S. Chapman R. A, Awdish, R.L. (2017). Role of Kindness in Cancer Care. Journal of Oncology Practice, 13(11):744-750.
Danaher, T.S, Brand S.R., Pickard, L.S.S, Mack J.W., Berry L.L. (2017). How a Child with Cancer Moved from Vulnerability to Resilience. Journal of Clinical Oncology, 35(27):3169-3171.
A/Prof Peter Downie AM
De Luca CR, Mulraney M, Anderson V, Downie P, Ma W, McCarthy MC (2022). Behavioral and Emotional Functioning of Children and Adolescents at the End of Treatment for Acute Lymphoblastic Leukemia Compared to Healthy Peers. J Clin Psychol Med Settings. Jun; 29(2):421-431
Chong WC, Jayasekera WSN, Vaghijani VG, Parackal S, Sun C, Popovoski D, Algar EM, Firestein R, Wood PJ, Khan S, Huang A, Ashley DM, Downie P, Cain JE. (2021). Atypical teratoid rhabdoid tumours are susceptible to Panobinostat-mediated differentiation therapy. Cancers (Basel). 2021. Oct 14;13(20):5145 (pp 1-19)
Zhou T, Khan S, Downie P, Cain JE (2019). Diffuse intrinsic pontine gliomas: translation of genomic knowledge to clinical practice.. OBM Neurobiology
Muscat A, Popovski D, Jayasekara WS, Rossello FJ, Ferguson M, Marini KD, Alamgeer M, Algar EM, Downie P, Watkins DN, Cain JE, Ashley DM (2016). Low-dose histone deacetylase inhibitor treatment leads to tumour growth arrest and multi-lineage differentiation of malignant rhabdoid tumours. Clin Cancer Res. 2016 Feb 26. [Epub ahead of print]
Pritchard-Jones K, Pieters R, Reaman GH, Hjorth L, Downie P, Calaminus G, Naafs-Wilstra MC, Steliarova-Foucher E (2013). Sustaining innovation and improvement in the treatment of childhood cancer: lessons from high-income countries. Lancet Oncol. 2013 Mar;14(3):e95-e103. Epub 2013 Feb 20
Prof David Eisenstat
Leung RF, George A, Roussel E, Faux M, Wigle JT, Eisenstat DD (2022). Genetic regulation of vertebrate forebrain development by homeobox genes. Frontiers in Neuroscience; 16; 843794.
Saran F, Eisenstat DD (2022). The relapse doesn’t fall far from the radiotherapy field: Lessons to be learned for the future of radiotherapy in medulloblastoma from the relapse patterns of SJMB03. Neuro-Oncology; 24(7): 1176-77.
Wu H, Wang B, Armstrong SR, Abuetabh Y, Leng S, Roa WHY, Atfi A, Marchese A, Wilson B, Sergi C, Flores ER, Eisenstat DD, Leng RP (2021). Hsp70 acts as a fine-switch that controls E3 Ligase CHIP-mediated TAp63 and deltaNp63 ubiquitination and degradation. Nucleic Acids Research; 49(5):2740-2758.
Merchant TE, Bendel AE, Sabin ND, Burger PC, Shaw DW, Chang E, Wu S, Zhou T, Eisenstat DD, Foreman NK, Fuller CE, Anderson ET, Hukin J, Lau CC, Pollack IF, Laningham FH, Lustig RH, Van Soelen ML, Armstrong FD, Handler MH, Williams-Hughes C, Kessel S, Kocak M, Ellison DW, Ramaswamy V (2019). Phase II trial of conformal radiation therapy for pediatric patients with localized ependymoma, chemotherapy before second surgery for incompletely resected ependymoma, and observation for completely resected, classic, supratentorial ependymoma. J Clin Oncol; 37(12):974-98.
McColl HD, Zagozewski JL, Eisenstat DD (2019). Chromatin immunoprecipitation (ChIP) protocols for the cancer and developmental biology laboratory. Brain Tumor Stem Cells: Methods and Protocols. Methods in Molecular Biology; 1869:143-153.
A/Prof Paul Ekert
Wong, M, Mayoh C, Lau L.M.S, Khuong-Quang D-A, Pinese M, Kumar A, Barahona P, Wilkie E.E., Sullivan P, Bowen-James R, Syed M, Martincorena I, Abascal F, Sherstyuk A, Bolanos N.A., Baber J, Priestley P, Dolman E.M.E, Fleuren E.D.G. … Ekert, P.G. & Cowley M.J. (2020). Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk paediatric cancer. Nature Medicine. DOI:10.1038/s41591-020-1072-4.
Hansen, J. K., Davidson N.M., Bjelosevic S, Morrish E, Brennan M.S., Oshlack A, Johnstone R.W. Brumatti G, Khaw S.L., Ekert, P.G., et al. (2020). MLL-TFE3: a novel and aggressive KMT2A fusion identified in infant leukaemia. Blood Advances, 4:4918-4923.
Brown L, Lonsdale A, Zhu A Davidson N.M., Schmidt B, Hawkins A, Wallach E, Martin M, Mechinaud F.M., Khaw S.L., Bartolo R.C., Ludlow L.E.A., Challis J, Brooks I, Petrovic V, Venn N.C., Sutton R, Majewski I.J., Oshlack A, Ekert, P.G. (2020). The application of RNA sequencing for the diagnosis and genomic classification of pediatric acute lymphoblastic leukemia. Blood Advances, 4: 930-942.
Khuong-Quang D.A, Brown L.M., Wong M, Mayoh C, Sexton-Oates A, Kumar A, Pinese M, Nagabushan S, Lau L, Ludlow L.E., Gifford A.J., Rodriguez M, Desai J, Fox S.B., Haber M, Ziegler D.S., Hansford J.R., Marshall G.M., Cowley M.J., Ekert, P.G., et al. (2020). Recurrent SPECC1L-NTRK fusions in paediatric sarcoma and brain tumours. Molecular Case Reports, 6(6). doi:10.1101/mcs.a005710.
Narayan N, Morenos L, Phipson B, Willis S.N., Brumatti G, Eggers S, Lalaoui N, Brown L.M., Kosasih H.J., Bartolo R.C., Zhou L, Catchpoole D, Saffery R, Oshlack A, Goodall G.J., Ekert, P.G., et al. (2016). Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukemia. Leukemia. doi:10.1038/leu.2016.279.
Prof Ron Firestein
Sun, C X, Daniel P, Bradshaw G, Gough D, Cain J E … Firestein R (2023). Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities. Cancer Cell 2023 Mar 22;S1535-6108(23)00080-6
Sooraj, D, Sun, C, Doan, A, Garama, D J, Dannappel, M V, Zhu, D, Chua, H K, Mahara, S, Hassan, W A W, Tay, Y K, Guanzio, A, Croagh, D, Prodanovic, Z, Gough, D J, Wan, C, Firestein, R (2022). MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase. Mol Cell. 2022 Jan 6;82(1):123-139.e7
Petralia, F, Tignor N, Reva B, Koptyra M, Chowdhury S, Rykunov D, Krek A, Ma W, Zhu Y, Ji J, Calinawan A, Whiteaker J.R., Colaprico A, Stathias V, Omelchenko T, Song X3, Raman P, Guo Y, Brown M.A. … Children’s Brain Tumor Network; Clinical Proteomic Tumor Analysis Consortium (2020). Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer. Cell, 183:1962-1985.
Dannappel, MV, Zhu D, Sun X, Chua HK, Poppelaars M, Suehiro M, Khadka S, Lim Kam Sian TKK, Sooraj D, Loi M, Gao H, Croagh D, Daly RJ, Faridi P, Boyer TG and Firestein R (2022). CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF. J Clin Invest . 2022 Oct 17;132(20):e15859
Wan C, Mahara S, Sun C, Doan A, Chua H, Xu D, Bian J, Li Y, Sooraj D, Cierpicki T, Grembecka J, Firestein R (2021). Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signalling identifies therapeutic targets for Colorectal Cancer. Sci Adv 2021; 7:eabf2567.
Prof Jordan Hansford
Capper D, Jones DTW, Sill M, Hovestadt V, Schrimpf D, Sturm D, Koelsche C, Sahm F, Chavez L, Reuss DE, Kratz A, Wefers AK, Huang K, Pajtler KW, Schweizer L, Stichel D, Olar A, Engel NW, Lindenberg K, Harter PN, Braczynski AK, Plate KH, Dohmen H, Garvalov BK, Coras R, Hölsken A, Hewer E, Bewerunge-Hudler M, Schick M, Fischer R, Beschorner R, Schittenhelm J, Staszewski O, Wani K, Varlet P, Pages M, Temming P, Lohmann D, Selt F, Witt H, Milde T, Witt O, Aronica E, Giangaspero F, Rushing E, Scheurlen W, Geisenberger C, Rodriguez FJ, Becker A, Preusser M, Haberler C, Bjerkvig R, Cryan J, Farrell M, Deckert M, Hench J, Frank S, Serrano J, Kannan K, Tsirigos A, Brück W, Hofer S, Brehmer S, Seiz-Rosenhagen M, Hänggi D, Hans V, Rozsnoki S, Hansford JR … Korshunov A, von Deimling A, Pfister SM (2018) DNA methylation-based classification of central nervous system tumours Nature 555 (7697), 469-47416672018
Bouffet E, Larouche V, Campbell BB, Merico D, de Borja R, Aronson M, Durno C, Krueger J, Cabric V, Ramaswamy V, Zhukova N, Mason G, Farah R, Afzal S, Yalon M, Rechavi G, Magimairajan V, Walsh MF, Constantini S, Dvir R, Elhasid R, Reddy A, Osborn M, Sullivan M, Hansford J, Dodgshun A, Klauber-Demore N, Peterson L, Patel S, Lindhorst S, Atkinson J, Cohen Z, Laframboise R, Dirks P, Taylor M, Malkin D, Albrecht S, Dudley RW, Jabado N, Hawkins CE, Shlien A, Tabori U (2016) Immune checkpoint inhibition for hypermutant glioblastoma multiforme resulting from germline biallelic mismatch repair deficiency Journal of clinical oncology 34 (19), 2206-22117222016
Kratz CP, Achatz MI, Brugières L, Frebourg T, Garber JE, Greer MC, Hansford JR, Janeway KA, Kohlmann WK, McGee R, Mullighan CG, Onel K, Pajtler KW, Pfister SM, Savage SA, Schiffman JD, Schneider KA, Strong LC, Evans DGR, Wasserman JD, Villani A, Malkin D (2017) Cancer screening recommendations for individuals with Li-Fraumeni syndrome Clinical Cancer Research 23 (11), e38-e453762017
Hansford JR, Mulligan LM (2000). Multiple endocrine neoplasia type 2 and RET: from neoplasia to neurogenesis Journal of Medical Genetics 37 (11), 817-8273112000
Pajtler KW, Mack SC, Ramaswamy V, Smith CA, Witt H, Smith A, Hansford JR … Bouffet E, Pfister SM, Taylor MD (2016). The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants Acta neuropathologica 133, 5-122692017
A/Prof Misty Jenkins
Abbott, R.C, Cross, R.S., Jenkins, M.R., et al. (2020). Finding the keys to the CAR: identifying novel target antigens for T cell redirection immunotherapies. International J Mol Sci, 21(2):515
Davenport A.J, Cross R.S., Watson K.A., Liao Y, Shi W, Prince H.M., Beavis P.A., Trapani J.A., Kershaw M.H., Ritchie D.S., Darcy P.K., Neeson P.J., Jenkins M.R., et al. (2018). Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity. Proc Nat Acad Sci, 115(9):E2068-E2076.
Jenkins M.R., Rudd-Schmidt J.A., Lopez J.A., Ramsbottom K.M., Mannering S.I., Andrews D.M., Voskoboinik I, Trapani J.A. (2015). Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time. J Exp Med, 212(3):307-17. 150
Davenport A.J, Jenkins M.R., Cross R.S., Yong C.S., Prince H.M., Ritchie D.S., Trapani J.A., Kershaw M.H., Darcy P.K., Neeson P.J. (2015). CAR-T cells inflict sequential killing of multiple tumor target cells. 2015. Cancer Immunology Research. Proc Nat Acad Sci, 3(5):483-94.
A/Prof Maria McCarthy
McCarthy M.C., De Abreu Lourenco R, McMillan L.J., Meshcheriakova E, Cao A, Gillam L. (2020). Finding Out What Matters in Decision-Making Related to Genomics and Personalized Medicine in Pediatric Oncology: Developing Attributes to Include in a Discrete Choice Experiment. The Patient-Patient-Centered Outcomes Research, 13:347-361.
Muscara, F, McCarthy, M.C., Rayner M, Nicholson J.M., Dimovski A, McMillan L, Hearps S.J.C., Yamada J, Burke K, Walser R, Anderson V.A. (2020). Effect of an online group intervention for traumatic stress in parents of children with life-threatening illness: A randomized clinical trial. JAMA Network Open, 3(7):e208507.
Garas A, McLean L.A., De Luca C.R., Downie P, McCarthy, M.C. (2019). Health-related quality of life in pediatric patients up to five years post-treatment completion for acute lymphoblastic leukemia: a systematic review. Supportive Care in Cancer, 27(11):4341-4351.
Darling S, De Luca C, Anderson V, McCarthy M, Hearps S, Seal M.L. (2018). White matter microstructure and information processing at the completion of chemotherapy-only treatment for pediatric Acute Lymphoblastic Leukemia. Developmental Neuropsychology, 43(5):385- 402.
McCarthy M.C., McNeil R, Drew S, Dunt D, Kosola S, Orme L, Sawyer S.M. (2016). Psychological distress and posttraumatic stress symptoms in adolescents and young adults with cancer and their parents. Journal Adolescent and Young Adult Oncology, 5(4):322-329.
Prof Paul Neeson
Meyran, D, Terry R.L., Zhu J.J., Haber M, Ziegler D.S., Ekert P.G., Trapani J.A, Darcy P.K., Neeson, P.J. (2021). Early-phenotype CAR-T cells for the treatment of pediatric cancers. Ann Oncol. S0923-7534(21)02506-0. doi: 10.1016/j.annonc.2021.07.018.
D’Souza, C, Keam S.P., Aw Yeang H.X., Neeson M, Richardson K, Hsu A.K., Canfield R, Bezman N, Robbins M, Quach H, Ritchie D.S., Harrison S.J., Trapani J.A., Prince H.M., Beavis P.A., Darcy P.K., Neeson, P.J.. (2021). Myeloma natural killer cells are exhausted and have impaired regulation of activation. Haematologica, 106(9):2522-2526. doi: 10.3324/haematol.2020.277525.
Keam S.P, Halse H, Nguyen T, Wang M, Van Kooten Losio N, Mitchell C, Caramia F, Byrne D.J., Haupt S, Ryland G, Darcy P.K., Sandhu S, Blombery P, Haupt Y, Williams S.G., Neeson, P.J. (2020). High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot. J Immunother Cancer, 8(1):e000792. doi: 10.1136/jitc-2020-000792.
Terry R.L, Meyran D, Ziergler D.S., Haber M, Ekert P.G., Trapani J.A., Neeson, P.J., et al. (2020). Immune profiling of pediatric solid tumors. J Clin Invest, 130(7):3391-3402. doi: 10.1172/JCI137181. PMID: 32538896.
Savas, P, Virassamy B, Ye C, Salim A, Mintoff C.P., Caramia F, Salgado R, Byrne D.J., Teo Z.L., Dushyanthen S, Byrne A, Wein L, Luen S.J., Poliness C, Nightingale S.S., Skandarajah A.S., Gyorki D.E., Thornton C.M., Beavis P.A. … Neeson, P.J. and Loi, S. (2018). Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis. Nat Med, 24(7):986-993. doi: 10.1038/s41591-018-0078-7.
A/Prof Sefi Rosenbluh
Davies, R, Liu L, Taotao S, Tuano N, Chaturvedi R, Huang K.K., Itman C, Mandoli A, Qamra A, Hu C, Powell D, Daly R.J., Tan P Rosenbluh, J. (2021). CRISPRi enables isoform specific loss-of-function screens and identification of gastric cancer specific isoform dependencies. Genome Biology, 22(1):47.
Li T, Kim A, Rosenbluh, J, Horn H, Greenfeld L, An D, Zimmer A, Liberzon A, Bistline J, Natoli T, Li Y, Tsherniak A, Narayan R, Subramanian A, Liefeld T, Wong N, Thompson D, Calvo S, Carr S. (2017). GeNets: A unified web platform for network-based analyses of genomic data. Nature Methods, 15(7):543-546.
Rosenbluh, J. Xu H, Harrington W, Gill S, Wang X, Vazquez F, Root D.E., Tsherniak A, Hahn W.C.. (2017). Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression. Nature Communications, 8: 15403.
Rosenbluh, J, Mercer J, Shrestha Y, Oliver R, Tamayo P, Doench J.G., Tirosh I, Piccioni F, Hartenian E, Horn H, Fagbami L, Root D.E., Jaffe J, Lage K, Boehm J.S., Hahn W.C. (2016). Integrated genetic and proteomic interrogation of WNT/β-catenin cancer dependencies. Cell Systems, 3(3):302- 316.
Kim J.W, Botvinnik O.B., Abudayyeh O, Birger C, Rosenbluh J, Shrestha Y, Abazeed M.E., Hammerman P.S., DiCara D, Konieczkowski D.J., Johannessen C.M., Liberzon A, Alizad-Rahvar A.R., Alexe G, Aguirre A, Ghandi M, Greulich H, Vazquez F, Weir B.A. … Tamayo P. (2016). Characterizing genomic alterations in cancer by complementary functional associations. Nature Biotechnology, 34(5):539-546.
Prof Melissa Southey
Breast Cancer Association Consortium, Dorling L, Carvalho S, Allen J, González-Neira A, Luccarini C, Wahlström C, Pooley K.A., Parsons M.T., Fortuno C, Wang Q, Bolla M.K., Dennis J, Keeman R, Alonso M.R., Álvarez N, Herraez B, Fernandez V, Núñez-Torres R, … Southey, M.C. … Easton D.F. (2021). Breast Cancer Risk Genes – Association Analysis in More than 113,000 Women. N Engl J Med.
Nguyen-Dumont T, MacInnis R.J., Steen J.A., Theys D, Tsimiklis H, Hammet F, Mahmoodi M, Pope B.J., Park D.J, Mahmood K, Severi G, Bolton D, Milne R.L., Giles G.G., Southey M.C., et al. (2020). Rare germline genetic variants and risk of aggressive prostate cancer. Int J Cancer, 147, (8), 2142-2149.
Yang, X, Leslie G, Doroszuk A, Schneider S, Allen J, Decker B, Dunning A.M., Redman J, Scarth J, Plaskocinska I, Luccarini C, Shah M, Pooley K, Dorling L, Lee A, Adank M.A., Adlard J, Aittomäki K, Andrulis I.L. … Southey, M.C. … Tischkowitz M. (2020). Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families. J Clin Oncol, 38, (7), 674-685.
Joo, J.E., Dowty J.G., Milne R.L., Wong E.M., Dugué P-A, English D, Hopper J.L., Goldgar D.E., Giles G.G., Southey M.C, kConFab. (2018). Heritable DNA methylation marks associated with susceptibility to breast cancer. Nat Commun, 9(1): 867.
Michailidou, K, Lindström S, Dennis J, Beesley J, Hui S, Kar S, Lemaçon A, Soucy P, Glubb D, Rostamianfar A, Bolla M.K., Wang Q, Tyrer J, Dicks E, Lee A, Wang Z, Allen J, Keeman R, Eilber U … Southey, M.C. … Easton, D.F. (2017). Association analysis identifies 65 new breast cancer risk loci. Nature, 551, (7678), 92-94.
A/Prof Lee Wong
Udugama M, Hii L, Garvie A, Cervini M, Vinod B, Chan F-L, Das P.P, Mann J.R., Collas P, Voon H.P.J., Wong L.H (2021). Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas. Nature Communication, 12(1), 2584. PMID: 33972520.
Voon H. P. J, Udugama M, Lin W, Hii L, Law R.H.P, Steer D.L., Das P.P., Mann J.R., Wong, L.H. (2018). Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma. Nature Communications, 9(1), 3142. PMID: 30087349.
Udugama M, Sanij E, Voon H.P.J., Son J, Hii L, Henson J.D., Chan F.L, Chang F.T.M, Liu Y, Pearson R.B., Kalitsis P, Mann J.R., Collas P, Hannan R.D., Wong, L.H. (2018). Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers. Proceedings of the National Academy of Sciences 115 (18), 4737-4742. PMID: 29669917.
Voon, H.P. & Wong, L. H. (2016) New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone. Nucleic Acids Res, 44(4): 1496-1501. PMID: 26773061.
Voon, H.P., Collas, P and Wong, L. H. (2016). Compromised heterochromatin promotes ALTernative lengthening of telomeres. Trends in Cancers, 2(3): 114-116. PMID: 28741530.
